Southampton came from behind to claim a crucial 2-1 win over Inter Milan at St Mary’s in Europa League Group K.
Mauro Icardi gave Inter a halftime lead when he turned in from close range following a goalmouth scramble.
But Southampton scored twice after the restart, including an own goal from Yuto Nagatomo.
Southampton remains second behind group leaders Sparta Prague, who defeated Hapoel Be’er Sheva.
Ever Banega had an early chance for Inter, but the forward was closed down in the box after Icardi picked off a poor pass deep in the Southampton half.
Southampton’s Jay Rodriguez, who replaced Charlie Austin in the starting line up, then curled an effort from the edge of the box over the bar inside 10 minutes.
But against the run of play, Icardi thrashed a left-footed shot past Fraser Forster from a scramble in the box after the ball found the forward standing on the six-yard box to give Inter a 1-0 lead on 34 minutes.
Southampton continued to press for an equaliser to no avail, until Pierre-Emile Hojbjerg earned a penalty for the hosts when his loose touch struck Ivan Perisic on the arm on the stroke of halftime.
After a melee in the box saw Antonio Candreva brandished a yellow card, Dusan Tadic stepped up only for his spot kick attempt to be saved by Samir Handanovic.
James Ward-Prowse nearly brought the hosts level on the restart, but his dipping volley found hits a dipping volley from distance into the keeper’s grasp.
The young Southampton midfielder then had his strike saved by a diving Handanovic on 50 minutes, who was also first to the rebound to deny a charging Rodriguez.
But Virgil van Dijk found a 64th-minute equaliser when Oriol Romeu’s lofted attempt careened back off the bar and onto the feet of the defender to slot home.
Tadic then had minor redemption for his missed penalty when his cross bounced off of Nagatomo and into the Inter net to give Southampton a 2-1 lead on 70 minutes.
Southampton: Forster, McQueen, van Dijk, Yoshida, Martina, Hojbjerg, Romeu, Ward-Prowse, Tadic (Davis 77), Redmond, Rodriguez (Austin 59).
Unused subs: Lewis (GK), Bertrand, Fonte, Clasie, Boufal.
Goals: van Dijk (64), Nagatomo (OG 70).
Bookings: Ward-Prowse (90+1).
Internazionale: Handanovic, Nagatomo, Ranocchia, Miranda, D’Ambrosio, Perisic, Gnoukouri (Melo 81), Medel (Eder 74), Candreva (Biabiany 89), Banega, Icardi (c).
Unused subs: Carrizo (GK), Ansaldi, Santon, Murillo.
Goals: Icardi (34).
Bookings: Candreva (45), Medel (52).