Southampton progressed to the Europa League play-offs after defeating Vitesse Arnhem at the GelreDome.
Graziano Pelle and Sadio Mane scored either side of the break with the former putting the visitors – who were emphatic across the tie – ahead within four minutes.
The Premier League side claimed a 5-0 aggregate win over their Eredivisie counterpart following a 3-0 victory at St Mary’s a week ago.
Southampton now await their opponent with the Europa League play-off draw in Switzerland set for August 7.
Vitesse squandered an early opportunity to claw back a goal under two minutes gone when Isaiah Brown thrashed wide.
Pelle punished his opponent at the other end two minutes later scoring with a low left-footed strike that had Eloy Room well beaten.
Milot Raschica then bounced a wide-open attempt to tie the game over the bar in the 8th minute while efforts by Maikel van der Werff and Valeri Kazaishvili both required the attention of goalkeeper Maarten Stekelenburg.
Mane nearly doubled the lead 10 minutes before the break but his shot was straight at the keeper.
After static midfield play opened the second half, Kazaishvili tried his luck from the edge of the box on the hour mark to no avail.
A quarter hour from time, Rashica had his shot deflected into the air by Yoshida but Stekelenburg won the resulting aerial battle and tipped the ball over.
Jay Rodriguez, who made his first competitive start since sustaining an injury 16-months ago, looked to add to the lead in the 83rd minute but he fired over the bar.
Mane doubled the lead on 89 minutes after dispossessing Danilo Pantic in the midfield before striking past Room.
Vitesse: Room, Diks, Kashia (c), Van der Werff (Achenteh 72′), Leerdam, Baker (Pantic 81′), Nakamba, Kazaishvili, Brown (Nathan 69’), Rashica, Oliynyk.
Unused subs: Velthuizen, Djurdjevic, Osman, Lelieveld.
Southampton: Stekelenburg, Caulker, Fonte (c), Yoshida, Martina, Wanyama, S. Davis (Reed 78’), Ward-Prowse, Tadić (Juanmi 65’), Mané, Pellè (Rodriguez 72’).
Unused subs: K. Davis (GK), Cédric, Targett, McQueen.
Bookings: Martina, Steklenburg.
Referee: Illías Spathas